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Prednisone to Prednisolone is impaired. Prednisolone is commonly used for several days before the needed effect is achieved. Prednisolone prevents the release of certain chemicals that are important in the immune system. Prednisone may interact with estrogens and phenytoin. It should be noted that it is very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders. Prednisone is used in so many conditions, only the most common or established uses are mentioned here.