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Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Keflex is a cephalosporin antibiotic used to treat a wide variety of bacterial infections. Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Keflex is a semi-synthetic cephalosporin antibiotic for oral administration. Take additional cephalosporin antibiotics as this is likely to result in an overdose. Cephalexin is contra-indicated in patients with known allergy to the cephalosporin group of antibiotics.