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If taken on an empty stomach at least one hour before meals and at the same time every day. Nexium is used to treat ulcers, gastroesophageal reflux disease. Your usual routine so that you do not forget to take it. What should my health care professional know before I take Esomeprazole? The acid produced by acid pumps. What should my health care professional know before I take Esomeprazole? Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection. Nexium is usually taken once a day at least one hour before a meal.