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The morning or evening, with or without food. This population. Paroxetine is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors approved by the FDA as a safe and effective for long-term use and is well tolerated. Symptoms associated with an unfavorable mental state need to be excessive and chronic to be considered to have in fact the medical problem of a major depressive disorder, as stated by others. Depression and anxiety disorders usually require long-term treatment because of their chronic nature and the risk of relapse. The medical problem of a major depressive disorder, as stated by others.