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Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using conjugated estrogens long term, especially if you smoke or are overweight. Long-term treatment with conjugated estrogens may increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Conjugated estrogens increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. This medication and call your doctor at once if you have had any circulation problem involving blood clots. Premarin is also controversial because the health risks to women of absorbing a substance made from equine waste may not be fully known.
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