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Steroid medication can weaken your immune system, making it easier for you to get an infection. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases. Steroid medication needs may change if you have surgery or a medical emergency. Prednisone is the most commonly-prescribed oral corticosteroid. A dose lasts about a day or a day and a half. Prednisone is used in so many conditions, only the most common or established uses are mentioned here.