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Lexapro affects chemicals in the brain, is an important factor in the development and severity of depressive symptoms, such as sad mood, fatigue, lack of pleasure, etc. Escitalopram appears to work by increasing the amount of serotonin, a chemical messenger in the brain that may become unbalanced and cause depression or anxiety. Within days of taking Lexapro you will notice an incredible change in your depression symptoms. Lexapro blocks the re-absorption of serotonin by the first nerve cell. There is a serious question about the safety and efficacy of initiating treatment with Lexapro to begin with. With minimal effect on many of the other chemicals in the brain, Lexapro may cause relatively few and mild side effects, which generally tend to go away with continued treatment. There is a serious condition that, if left untreated, can cause major problems in your life.