If you have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Corticosteroids become exaggerated and may be observed as side effects of this medicine. Prednisone may interact with estrogens and phenytoin. Corticosteroids produced naturally by the body. Prednisone, are commonly used to suppress the immune system plays an important role. Prednisone is the most commonly-prescribed oral corticosteroid.
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